For the schizophrenia P2), we subdivided seen schizophrenia-centered PRS on ALS cohort toward deciles and computed the chances ratio if you are an ALS case during the for every decile opposed towards the earliest decile playing with an identical generalized linear model:
Chance ratios and you can 95% trust periods getting ALS had been derived of the figuring the newest rapid setting of one’s beta imagine of your own model for each and every of one’s deciles 2–ten.
Diagnostic misclassification
To distinguish the contribution of misdiagnosis from true genetic pleiotropy we used BUHMBOX 21 with 417 independent ALS risk alleles in a sample of 27,647 schizophrenia patients for which individual-level genotype data were available. We also estimated the required misdiagnosis rate M of FTD–ALS as schizophrenia that would lead to the observed genetic correlation estimate as C/(C+1), where C=? Read More T for which we obtained the higramshest ? explained variance (0